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Polynucleotides explained with benefits, safety, expected results and comparisons to Dermal Fillers, Profhilo, Sunekos, and Sculptra
If you’re seeking skin results that look like you just got back from holiday, spent time away from screens, and are managing to drink three litres of water daily, then Polynucleotides might just be the aesthetic treatment for you.
This next-generation injectable has quickly gained popularity amongst patients and aesthetic professionals alike – and for good reason. Rather than relaxing muscle movement like Anti Wrinkle Injections or adding volume like Dermal Fillers, Polynucleotides work with your skin’s own biology to regenerate, repair, and rejuvenate from within.
At the Anti Wrinkle Clinic, I’ve seen a rise in patients wanting treatments that go beyond temporary fixes. They don’t just want smoother skin, they want healthier skin - and Polynucleotides fit that brief perfectly.
In this blog, I’ll explain what Polynucleotides are, how they work, how they compare to other aesthetic treatments so you can make an informed decision.
In the pursuit of healthier, more resilient skin, there has been a clear movement toward injectables that support the skin’s natural functions. Polynucleotides are a great example of this shift. They’re sometimes jokingly referred to as the “salmon sperm treatment” — a nickname that often raises my patients’ eyebrows — but there’s solid science behind it.
Polynucleotides are purified DNA fragments of trout or salmon’s milt. These DNA chains are carefully extracted, filtered, and sterilised to medical-grade standards, making them safe and suitable for injection. While the origin may sound quite bizarre at first, Polynucleotides have been used in regenerative medicine for many years and are supported by both clinical experience and scientific research [2].
In aesthetic medicine, Polynucleotides are used to support the skin’s own repair mechanisms. Rather than trying to superficially hide or mask ageing changes, they actually help improve tissue quality, hydration, and resilience from within. This makes them particularly appealing for patients who are prioritising natural-looking results.
As we age, the skin’s ability to repair itself slows down. Collagen and elastin production starts to decline, cell turnover becomes less efficient, hydration decreases, and the skin becomes more vulnerable to environmental stress [2].
Polynucleotides can help address these concerns because they act as biological stimulators. Once injected, they begin activating fibroblasts – the cells responsible for producing collagen and elastin – helping to strengthen the skin’s structural framework over time [2]. They also support extracellular matrix repair, which is essential for maintaining firmness, elasticity, and overall skin integrity [2].
Additionally, Polynucleotides have some pretty remarkable regenerative effects. They help improve microcirculation and angiogenesis, allowing better delivery of oxygen and nutrients to the skin [4]. They also demonstrate anti-inflammatory and antioxidant activity, which helps reduce oxidative stress and supports tissue repair [1]. Overall, this creates a much healthier cellular environment, enabling the skin to function more efficiently and recover more effectively.
Adding another notch to their belt, Polynucleotides are highly biocompatible. Because they closely resemble naturally occurring DNA fragments in the human body, they are well tolerated and our skin doesn’t regard them as a threat [2]. So, rather than forcing change in a superficial way, they actually support regeneration, making them suitable even for delicate or sensitive areas – such as the under-eyes.
Because they work with the skin’s natural biology, Polynucleotides can lead to gradual but truly meaningful improvements in skin quality. Common benefits I see in patient results include smoother texture, improved hydration, increased elasticity, and a more resilient skin barrier [3].
As collagen and elastin production begins to improve, Polynucleotides can help soften fine lines and early wrinkles over time [3]. And by enhancing microcirculation and cellular repair, the skin starts to appear brighter, healthier, and more rested rather than showing an obvious “treated” look [4].
There is also emerging evidence that Polynucleotides may support more even skin tone. Some studies suggest they can influence the process responsible for pigment production in the skin [7]. I’m keeping an eye on this, as evidence is still emerging and results vary between individuals - but for right now, Polynucleotides do not replace established pigmentation treatments. However, they may play a supportive role in improving overall skin clarity and recovery, particularly in skin affected by inflammation or environmental damage.
While many injectables are designed to either relax muscle movement, replace lost volume, or deliver hydration, Polynucleotides focus on improving the biological quality of the skin itself.
Understanding these differences as a patient is important. That’s why I make sure your initial consultation – the Face-to-face hour – is a full 60-minutes. Because choosing the right treatment is not about what is “better,” but about understanding and considering what concerns you are trying to address.
Dermal Fillers are designed to restore volume, structure, and contour. They provide immediate results and remain in place due to their cross-linked composition. Polynucleotides do not add volume or alter facial shape. Instead, they improve the quality of the skin itself by enhancing hydration, elasticity, and tissue repair [3].
In simple terms, Dermal Fillers address structural volume loss, while Polynucleotides address skin quality and tissue health.
Both of these treatments aim to improve skin quality, but they do so through different mechanisms. Profhilo spreads evenly beneath the skin to deliver deep hydration and improve elasticity and firmness. Polynucleotides focus more on cellular repair, tissue regeneration, and skin resilience [3].
While Profhilo excels at hydration and tightening, Polynucleotides provide broader regenerative support, particularly for patients whose skin is weakened, damaged, or inflamed.
Sunekos combines hyaluronic acid with amino acids to stimulate collagen and elastin and fibronectin production. It is particularly effective for improving elasticity, hydration, and fine lines. Polynucleotides, on the other hand, focus on deeper tissue repair and anti-inflammatory support [2].
Although Sunekos and Polynucleotides work in different ways, I use both treatments regularly and in many of the same areas of the face. They are especially useful for the under-eye area, which is notoriously difficult to treat as the skin in the periorbital region becomes thinner, drier, looser, and more textured with age [5].
In the past, treatment options here were limited because only a small number of patients were suitable for tear trough Dermal Fillers. Treatments like Sunekos and Polynucleotides have changed that. By focusing on improving skin quality rather than adding volume, they allow me to treat under-eye ageing more safely and subtly in a wider range of patients [2][3].
Sculptra is a collagen-stimulating injectable made from poly-L-lactic acid. It works by creating a controlled inflammatory response in the deeper layers of the skin, encouraging the body to produce new collagen over time [11][12]. This makes Sculptra particularly effective for restoring facial volume, improving structural support, and addressing more advanced signs of volume loss. Results develop gradually and are typically focused on lifting and contour rather than surface skin quality.
Polynucleotides, on the other hand, do not rely on an inflammatory mechanism. Instead, they support cellular repair, fibroblast activity, and tissue regeneration in a more physiological and biocompatible way [2][3]. Because of their high biocompatibility, Polynucleotides are also suitable for more delicate areas where Sculptra would not be appropriate [5][6].
Polynucleotides integrate extremely well into comprehensive treatment plans and I often use them alongside other injectables to enhance overall results. In my experience, structuring treatments correctly is key to achieving natural, balanced outcomes.
Dermal Fillers restore volume, contour, and structure, while Polynucleotides improve the quality of the skin itself. I often recommend starting with Polynucleotides to strengthen and hydrate the skin before introducing Dermal Fillers. This approach creates a healthier foundation, allowing fillers to sit more smoothly and naturally, and in some cases may help optimise their longevity [3].
Anti Wrinkle Injections work by reducing muscle activity to soften dynamic lines and prevent them from deepening. Polynucleotides complement this by improving skin texture, hydration, and resilience. Used together, they address both the muscular and skin-quality components of facial ageing, leading to more refined and natural-looking results.
Profhilo Structura is designed to target superficial fat compartments and improve lifting and contour. Polynucleotides can help enhance their effect by supporting the surrounding tissue, improving skin quality, and enhancing tissue resilience. When combined, these treatments can produce a noticeable improvement in firmness and overall facial support without an over-treated appearance.
Sculptra addresses deeper structural ageing, while Polynucleotides optimise the quality of the overlying skin. When used together in a staged and considered way, they can produce more harmonious, natural-looking results than either treatment alone.
Microneedling stimulates controlled skin injury to promote repair and increase product absorption. When Polynucleotides are introduced alongside Microneedling, their regenerative and hydrating effects may be amplified. This combination is particularly effective for improving texture, radiance, and overall skin quality [3].
Polynucleotides can be used on the face neck, décolletage, and hands. One of my favourite and most valuable applications is the under-eye area, which is particularly delicate and unsuitable for many injectable treatments.
Different Polynucleotide formulations allow tailored treatment of this area. Some are used superficially to improve skin quality, hydration, and fine lines, while higher-concentration formulations can be placed more deeply to support hollows and structural weakness [5]. This approach allows subtle rejuvenation for all those patients where filler is not indicated.
Polynucleotides are also increasingly used on the scalp. Clinical studies suggest they may support scalp tissue health, improve vascularisation, and contribute to improved hair density in certain types of hair thinning [8][9][10]. While not a standalone solution for hair loss, they can form part of a broader regenerative approach. Keep an eye out, as I’ll be looking to add this treatment to our options this year!
Overall, Polynucleotides are particularly suitable for patients seeking natural, gradual improvement, and for those who have found other treatments too aggressive, too obvious, or too short-lived.
A typical Polynucleotide session takes around 30 minutes. If it’s your first time booking Polynucleotides, a course of three to four treatments spaced a few weeks apart is recommended, followed by one or two maintenance sessions every 5 months.
Results develop gradually rather than immediately. Visible improvement usually begins after three to four weeks and continues to build over the following months as the skin regenerates [3].
Downtime is minimal but not nonexistent. Mild redness, swelling, small bumps, or bruising at injection sites can occur, particularly when treating the under-eyes as this area is so delicate. These effects typically resolve within a few days, though some patients may experience visible swelling for up to two to four days [6].
Polynucleotides are generally well tolerated due to their high biocompatibility [6]. However, they are not suitable for everyone. Patients with fish or seafood allergies should avoid this treatment, and it is not recommended during pregnancy, breastfeeding, or for individuals with certain autoimmune or bleeding disorders. A full medical consultation is essential before treatment.
At the Anti Wrinkle Clinic, I’ve chosen brands based on safety profile, clinical evidence, and suitability for different treatment areas. This allows me to tailor Polynucleotide treatments to your individual needs, whether the goal is improving skin quality, addressing delicate areas, or supporting deeper tissue repair.
In my experience, while treatments such as Dermal Fillers, Anti Wrinkle Injections, Profhilo, Sunekos, and Sculptra each offer specific benefits, Polynucleotides stand out for their ability to enhance skin quality gradually and naturally, both as a standalone treatment and in combination with others.
If you’re interested in whether Polynucleotides could help address your skin concerns, I invite you to book your Face-to-face hour with me. We’ll spend a 60-minutes discussing your skin, your goals, and the most appropriate treatment options for you, with no pressure to proceed until you’re completely comfortable. New patients receive £100 off this initial consultation.
[1] Bitto A, et al. Polydeoxyribonucleotide reduces inflammation and oxidative stress and improves tissue repair. Journal of Biological Regulators and Homeostatic Agents. 2008.
[2] Guizzardi S, et al. Polydeoxyribonucleotide (PDRN): molecular mechanisms and clinical applications in tissue repair. International Journal of Molecular Sciences. 2020.
[3] Kim JH, et al. Clinical applications of polydeoxyribonucleotide in dermatology and aesthetic medicine. Clinical, Cosmetic and Investigational Dermatology. 2018.
[4] Galeano M, et al. Polydeoxyribonucleotide improves wound healing by stimulation of angiogenesis. Wound Repair and Regeneration. 2008.
[5] Savoia A, et al. Use of polynucleotides in periocular rejuvenation. Journal of Cosmetic Dermatology. 2019.
[6] Zelenkova H, et al. Safety and tolerability of injectable polynucleotides in aesthetic practice. Aesthetic Medicine Journal. 2021.
[7] Kim YJ, et al. Effect of polydeoxyribonucleotide on melanogenesis and pigmentation. Annals of Dermatology. 2016.
[8] Lee JH, et al. Polydeoxyribonucleotide in the treatment of androgenetic alopecia. Journal of Dermatological Treatment. 2017.
[9] Kang JS, et al. Angiogenic and regenerative effects of polydeoxyribonucleotide in scalp tissue. Experimental Dermatology. 2014.
[10] Gentile P, et al. Regenerative approaches in hair loss treatment. Stem Cells and Cloning: Advances and Applications. 2020.
[11] Vleggaar D, Fitzgerald R. Facial volume restoration with poly-L-lactic acid. Dermatologic Surgery. 2008.
[12] Narins RS, et al. A randomized study of poly-L-lactic acid for facial volume loss. Journal of the American Academy of Dermatology. 2010.
Yes – every treatment at the Anti Wrinkle Clinic starts with a consultation. This is an important step to make sure the treatment you’re considering is both suitable and safe for you. During your consultation, I’ll take the time to understand your goals, review your medical history, and discuss what’s best for your skin.
Please note that payment doesn’t automatically guarantee a treatment. If anything comes up during your consultation that makes a procedure unsafe or unsuitable, I will explain why and recommend alternative options.
Polynucleotides are purified DNA fragments, most commonly derived from fish such as salmon or trout. Fish DNA is structurally very similar to human DNA and is extremely well tolerated by the body. That’s one of the reasons it’s so useful in regenerative treatments. The DNA goes through extensive purification and sterilisation to medical-grade standards before it’s ever used in a treatment. What I’m injecting is not living material, but a highly refined, biocompatible substance designed to work safely with human tissue.
When used appropriately and performed by a trained medical injector (like myself), Polynucleotides are generally very well tolerated. Their high biocompatibility means adverse reactions are uncommon. As with any injectable treatment, safety starts with careful patient selection, correct product choice, and proper technique – which is exactly why every patient I treat undergoes a full medical consultation first.
Polynucleotides are not a one-off, instant-result treatment. They work by encouraging your skin to repair and regenerate itself, and that process takes time. Rather than adding volume or freezing movement, Polynucleotides send signals to the skin to improve collagen production, hydration, and overall skin health.
Each treatment builds on the one before it. Spacing sessions around two weeks apart gives your skin enough time to respond to the treatment and start the repair process before it is stimulated again. This timing helps create a steady, cumulative improvement without overwhelming the skin.
Completing a course of three sessions allows these regenerative signals to be repeated, leading to more consistent and longer-lasting improvements in skin quality, resilience, and hydration. It also allows me to see how your skin responds and adjust future treatments or maintenance plans to suit you.
Even though this isn’t an instant-result treatment, most patients start noticing improvements in skin quality 2 weeks after the first session, with continued improvement over the following month. I always explain this upfront so expectations are realistic – the results are gradual, but they’re also very natural.
Yes – and this is one of the areas I find particularly valuable! Polynucleotides are one of the few injectable treatments that can safely improve under-eye skin quality. Depending on the product and technique used, they can help with hydration, fine lines, sagging skin, and in some cases support under-eye hollows.
This is a question I’m asked quite often, and it’s a valid one. The short answer is no. Polynucleotides are sourced from controlled and sustainable fish stocks, and the manufacturing process uses very small amounts of purified DNA fragments.
The products I use are produced by reputable medical manufacturers that follow strict ethical and environmental standards. In practice, this means Polynucleotide treatments do not contribute to overfishing or harm marine ecosystems.
At the Anti Wrinkle Clinic, I only work with established, medical-grade Polynucleotide brands that have a strong safety profile and clinical evidence behind them. The main brands I use are Ameela and Plinest.
Plinest is one of the longest-established Polynucleotide brands and has a solid evidence base, making it particularly reliable for improving overall skin quality and tissue repair.
Ameela offers more specialised formulations, including products specifically designed for the under-eye area. For example, I use Ameela Eye for under-eye skin quality and Ameela Rejuvenation when supporting under-eye hollows.
Using different brands and formulations allows me to tailor treatments properly rather than using a one-size-fits-all approach. During your consultation, I’ll always explain which product I’m recommending and why, based on your anatomy, skin quality, and goals.
All treatments are personally performed by Dr Yiannis (that’s me!), a fully qualified medical aesthetic practitioner with over 20 years of experience. My academic and clinical background includes:
Over the past 20 years, I have also completed extensive postgraduate training in facial aesthetics, participating in numerous advanced, hands-on training modules both in the UK and across Europe. This includes training delivered by internationally recognised experts in medical aesthetics as well as by the pharmaceutical and medical device companies whose products I use in clinic, ensuring my techniques are up to date, evidence-based, and aligned with the highest safety standards.
Everything that happens at the Anti Wrinkle Clinic, I personally carry out – ensuring consistency, safety, and care from start to finish.
Yes – all injectable treatments at the Anti Wrinkle Clinic are prescription-only and fully regulated under UK medical guidelines. Treatments are prescribed and administered exclusively by Dr Yiannis, following an in-person consultation to confirm suitability.
More significant side effects are rare but you should be mindful that they can happen. These can include bruising, infection, or allergic reaction.
Rest assured, we follow strict clinical and hygiene protocols, source products only from licensed UK pharmacies.
For the first 24 hours, I recommend all my patients take it easy. You can certainly cleanse and moisturise the skin, but please avoid rubbing or massaging the treated areas. Wearing makeup is perfectly fine, but keep it light-handed. It’s also a good idea to skip strenuous exercise, saunas, steam rooms, and hot yoga for the rest of the day.
For the next 1-2 weeks, I would also recommend staying clear of facials, peels, and microneedling. Importantly, I urge you to use daily SPF (30-50) and keep hydrated. Remember – good skincare supports great treatment results.
If you experience any unusual symptoms – be that pain, discomfort, itching, redness, then please contact the clinic immediately on +44 20 3598 7358
Learn more about our unique consultation process, your Face-to-face hour – a dedicated 60-minute, in-person appointment with Dr Yiannis.
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